Ch49. Diagnosis and Management of Pelvic Fractures in the Thoroughbred Racehorse > Fibrotic myopathy > Ch97. Poor Performance and Lameness > Ch62. Markers of Osteoarthritis: Implications for Early Diagnosis and Monitoring of the Pathological Course and Effects of Therapy > Ch68. Pathophysiology of Tendon Injury

Ch68. Pathophysiology of Tendon Injury

  1. Alexander RM: Energy-saving mechanisms in walking and running, J Exp Biol 160:55, 1991. PUBMED Abstract
  2. Wilson AM, McGuigan MP, Su A, et al: Horses damp the spring in their step, Nature 414:895, 2001. PUBMED Abstract
  3. Wilson AM, van den Bogert AJ, McGuigan MP: Optimization of the muscle-tendon unit for economical locomotion in cursorial animals. In Herzog W, ed: Skeletal muscle mechanics: from mechanisms to function, Chichester, England, 2000, John Wiley & Sons.
  4. Screen HR, Lee DA, Bader DL, et al: An investigation into the effects of the hierarchical structure of tendon fascicles on micromechanical properties, Proc Inst Mech Eng H 218:109, 2004. PUBMED Abstract
  5. Wilson AM: The effect of exercise intensity on the biochemistry, morphology, and mechanical properties of tendon, PhD thesis, Bristol, United Kingdom, 1991, University of Bristol.
  6. Woo SL: Mechanical properties of tendons and ligaments. I. Quasi-static and nonlinear viscoelastic properties, 19:385, 1982. PUBMED Abstract
  7. Viidik A: Tensile strength properties of Achilles tendon systems in trained and untrained rabbits, Acta Orthop Scand 40:261, 1969. PUBMED Abstract
  8. Goodship AE, Birch HL, Wilson AM: The pathobiology and repair of tendon and ligament injury, Vet Clin North Am Equine Pract 10:323, 1994. PUBMED Abstract
  9. Crevier N, Pourcelet P, Denoix J-M, et al: Segmental variations of in vitro mechanical properties in equine superficial digital flexor tendons, Am J Vet Res 57:1111, 1996. PUBMED Abstract
  10. Riemersma DJ, van der Bogert AJ, Jansen MO, et al: Tendon strain in the forelimbs as a function of gait and ground characteristics and in vitro limb loading in ponies, Equine Vet J 28:133, 1996. PUBMED Abstract
  11. Stephens PR, Nunamaker DM, Butterweck DM: Application of a Hall-effect transducer for measurement of tendon strains in horses, Am J Vet Res 56:1089, 1989. PUBMED Abstract
  12. Riemersma DJ, Schamhardt HC: In vitro mechanical properties of equine tendons in relation to cross-sectional area and collagen content, Res Vet Sci 39:263, 1985. PUBMED Abstract
  13. Wilson AM, Goodship AE: Exercise-induced hyperthermia as a possible mechanism for tendon degeneration, J Biomech 27:899, 1994. PUBMED Abstract
  14. Batson EL, Paramour RJ, Smith T, et al: Are the material properties and matrix composition of equine flexor and extensor tendons determined by their functions? Equine Vet J 35:314, 2003. PUBMED Abstract
  15. Wilmink J, Wilson AM, Goodship AE: Functional significance of the morphology and micromechanics of collagen fibres in relation to partial rupture of the superficial digital flexor tendon in racehorses, Res Vet Sci 53:354, 1992. PUBMED Abstract
  16. Patterson-Kane JC, Parry DA, Birch HL, et al: An age-related study of morphology and cross-link composition of collagen fibrils in the digital flexor tendons of young thoroughbred horses, Connect Tissue Res 36:253, 1997. PUBMED Abstract
  17. Canty EG, Kadler KE: Procollagen trafficking, processing and fibrillogenesis, J Cell Sci 118:1341, 2005. PUBMED Abstract
  18. Holmes DF, Graham HK, Trotter JA, et al: STEM/TEM studies of collagen fibril assembly, Micron 32:273, 2001. PUBMED Abstract
  19. Kadler KE, Holmes DF, Trotter JA, et al: Collagen fibril formation, Biochem J 316:1, 1996. PUBMED Abstract
  20. Kadler KE, Holmes DF, Graham H, et al: Tip-mediated fusion involving unipolar collagen fibrils accounts for rapid fibril elongation, the occurrence of fibrillar branched networks in skin and the paucity of collagen fibril ends in vertebrates, Matrix Biol 19:359, 2000. PUBMED Abstract
  21. Smith RK, Goodship AE: Tendon physiology: responses to exercise and training. In Hinchcliffe K, Kaneps A, Geor R, eds: Equine sports medicine and surgery, St Louis, 2004, Elsevier.
  22. Kraus-Hansen AE, Fackelman GE, Becker C, et al: Preliminary studies on the vascular anatomy of the equine superficial digital flexor tendon, Equine Vet J 24:46, 1992. PUBMED Abstract
  23. Kraus BLH, Kirker-Head CA, Kraus KH, et al: Vascular supply of the tendon of the equine deep digital flexor muscle within the digital sheath, Vet Surg 24:102, 1995. PUBMED Abstract
  24. Jones AJ: Normal and diseased equine digital flexor tendon: blood flow, biochemical and serological studies, PhD thesis, London, 1993, University of London.
  25. Strömberg B: The normal and diseased superficial digital flexor tendon in racehorses: a morphologic and physiologic investigation, Acta Radiol 305(Suppl):1, 1971.
  26. Smith RK, Webbon PM: The physiology of normal tendon and ligament. Rantanen NW, Hauser ML, eds: Proceedings of the 1996 Dubai International Equine Symposium, Bonsall, Calif, 1996, Matthew R Rantanen Design.
  27. Stanley R, Goodship AE, Edwards B, et al: Effects of exercise on tenocyte cellularity and tenocyte nuclear morphology in immature and mature equine digital tendons, Equine Vet 40:141, 2008. PUBMED Abstract
  28. Goodman SA, May SA, Heinegård D, et al: Tenocyte response to cyclical strain and transforming growth factor beta is dependent upon age and site of origin, Biorheology 41:613, 2004. PUBMED Abstract
  29. Webbon PM: A histological study of macroscopically normal equine digital flexor tendons, Equine Vet J 10:253, 1978. PUBMED Abstract
  30. Cauvin ERJ: An investigation into the roles of transforming growth factor beta (TGFβ) in the development, adaptation, and repair of equine tendon, PhD dissertation, London, 2001, University of London.
  31. Bi Y, Ehirchiou D, Kilts TM, et al: Identification of tendon stem/progenitor cells and the role of the extracellular matrix in their niche, Nat Med 13:1219, 2007. PUBMED Abstract
  32. Salingcarnboriboon R, Yoshitake H, Tsuji K, et al: Establishment of tendon-derived cell lines exhibiting pluripotent mesenchymal stem cell–like property, Exp Cell Res 287:289, 2003. PUBMED Abstract
  33. Strassburg S: Adult and late foetal equine tendon contain cell populations with weak progenitor properties in comparison to bone marrow derived mesenchymal stem cells, Proc Orthop Res Soc 52, 2006.
  34. Banes AJ, Tsuzaki M, Yamamoto J, et al: Mechanoreception at the cellular level: the detection, interpretation, and diversity of responses to mechanical stimuli, Biochem Cell Biol 73:349, 1995. PUBMED Abstract
  35. McNeilly CM, Banes AJ, Benjamin M, et al: Tendon cells in vivo form a three dimensional network of cell processes linked by gap junctions, J Anat 189:593, 1996. PUBMED Abstract
  36. Murphy DJ, Nixon AJ: Biochemical and site-specific effects of insulin-like growth factor I on intrinsic tenocyte activity in equine flexor tendons, Am J Vet Res 58:103, 1997. PUBMED Abstract
  37. Dahlgren LA, van der Meulen MC, Bertram JE, et al: Insulin-like growth factor–I improves cellular and molecular aspects of healing in a collagenase-induced model of flexor tendinitis, J Orthop Res 20:910, 2002. PUBMED Abstract
  38. Frank C, Woo S, Andriacchi T, et al: Normal ligament: structure, function, and composition. In Woo SL-Y, Buckwalter JA, eds: Injury and repair of musculoskeletal soft tissues, Park Ridge, Ill, 1987, American Academy of Orthopaedic Surgeons.
  39. Silver IA, Brown PN, Goodship AE, et al: A clinical and experimental study of tendon injury, healing, and treatment in the horse, Equine Vet J Suppl 1:1, 1983. PUBMED Abstract
  40. Hedbom E, Antonsson P, Hjerpes A, et al: Cartilage matrix proteins: an acidic oligomeric protein (COMP) detected only in cartilage, J Biol Chem 267:6132, 1992. PUBMED Abstract
  41. Mörgelin M, Heinegård D, Engel J, et al: Electron microscopy of native cartilage oligomeric matrix protein purified from the Swarm rat chondrosarcoma reveals a five-armed structure, J Biol Chem 267:6137, 1992. PUBMED Abstract
  42. Smith RK, Zunino L, Webbon PM, et al: The distribution of cartilage oligomeric matrix protein (COMP) in tendon and its variation with tendon site, age and load, Matrix Biol 16:255, 1997. PUBMED Abstract
  43. Rosenberg K, Olsson H, Morgelin M, et al: Cartilage oligomeric matrix protein shows high affinity zinc-dependent interaction with triple helical collagen, J Biol Chem 273:20397, 1998. PUBMED Abstract
  44. Thur J, Rosenberg K, Nitsche DP, et al: Mutations in cartilage oligomeric matrix protein causing pseudoachondroplasia and multiple epiphyseal dysplasia affect binding of calcium and collagen I, II, and IX, J Biol Chem 276:6083, 2001. PUBMED Abstract
  45. Hecht JT, Nelson LD, Crowder E, et al: Mutations in exon 17B of cartilage oligomeric matrix protein (COMP) cause pseudoachondroplasia, Nat Genet 10:325, 1995. PUBMED Abstract
  46. Briggs MD, Hoffman SM, King LM, et al: Pseudoachondroplasia and multiple epiphyseal dysplasia due to mutations in the cartilage oligomeric matrix protein gene, Nat Genet 10:330, 1995. PUBMED Abstract
  47. Halasz K, Kassner A, Mörgelin M, et al: COMP acts as a catalyst in collagen fibrillogenesis, J Biol Chem 282:31166, 2007. PUBMED Abstract
  48. Smith RK, Gerard M, Dowling B, et al: Correlation of cartilage oligomeric matrix protein (COMP) levels in equine tendon with mechanical properties: a proposed role for COMP in determining function-specific mechanical characteristics of locomotor tendons, Equine Vet J Suppl 34:241, 2002. PUBMED Abstract
  49. Brown DC, Vogel KG: Characteristics of the in vitro interaction of a small proteoglycan (PG II) of bovine tendon with type I collagen, Matrix 9:468, 1989. PUBMED Abstract
  50. Danielson KG, Baribault H, Holmes DF, et al: Targeted disruption of decorin leads to abnormal collagen fibril morphology and skin fragility, J Cell Biol 136:729, 1997. PUBMED Abstract
  51. Svensson L, Aszódi A, Reinholt FP, et al: Fibromodulin-null mice have abnormal collagen fibrils, tissue organization, and altered lumican deposition in tendon, J Biol Chem 274:9636, 1999. PUBMED Abstract
  52. Avella CS, Ely ER, Verheyen KL, et al: Ultrasonographic assessment of the superficial digital flexor tendon of National Hunt racehorses in training over two racing seasons, Equine Vet J 41:449, 2009. PUBMED Abstract
  53. Pickersgill C: Epidemiological studies into orthopaedic conditions of the equine athlete, MVM thesis, Glasgow, 2000, University of Glasgow.
  54. Webbon PM: Post mortem study of equine digital flexor tendons, Equine Vet J 9:61, 1977. PUBMED Abstract
  55. Patterson-Kane JC, Firth EC, Parry DAD, et al: Comparison of collagen fibril populations in the superficial digital flexor tendons of exercised and nonexercised thoroughbreds, Equine Vet J 29:121, 1997. PUBMED Abstract
  56. Patterson-Kane JC, Wilson AM, Firth EC, et al: Exercise-related alterations in crimp morphology in the central regions of the superficial digital flexor tendons from young thoroughbreds: a controlled study, Equine Vet J 30:61, 1998. PUBMED Abstract
  57. Birch HL, Wilson AM, Goodship AE: Physical activity: does long-term, high-intensity exercise in horses result in tendon degeneration? J Appl Physiol 105: 1927, 2008. PUBMED Abstract
  58. Smith RKW, Birch H, Patterson-Kane J, et al: Should equine athletes commence training during skeletal development? changes in tendon matrix associated with development, ageing, function, and exercise, Equine Vet J Suppl 30:201, 1999. PUBMED Abstract
  59. Smith RK, Birch HL, Goodman S, et al: The influence of ageing and exercise on tendon growth and degeneration—hypotheses for the initiation and prevention of strain-induced tendinopathies, Comp Biochem Physiol A Mol Integr Physiol 133:1039, 2002. PUBMED Abstract
  60. Birch HL, Bailey AJ, Goodship AE: Macroscopic “degeneration” of equine superficial digital flexor tendon is accompanied by a change in extracellular matrix composition, Equine Vet J 30:534, 1998. PUBMED Abstract
  61. Cherdchutham W, Becker C, Smith RK, et al: Age-related changes and the effect of exercise on the molecular composition of immature equine superficial digital flexor tendons, Equine Vet J Suppl 31:86, 1999. PUBMED Abstract
  62. Kasashima Y, Takahashi T, Smith RK, et al: Prevalence of superficial digital flexor tendonitis and suspensory desmitis in Japanese Thoroughbred flat racehorses in 1999, Equine Vet J 36:346, 2004. PUBMED Abstract
  63. Haglund-Akerlund Y, Eriksson E: Range of motion, muscle torque and training habits in runners with and without Achilles tendon problems, Knee Surg Sports Traumatol Arthrosc 1:195, 1993. PUBMED Abstract
  64. Neuberger A, Slack HGB: Metabolism of collagen from liver, bone, skin and tendon in normal rat, Biochem J 53:47, 1953. PUBMED Abstract
  65. Perez-Castro AV, Vogel KG: In situ expression of collagen and proteoglycan genes during development of fibrocartilage in bovine deep flexor tendon, J Orthop Res 17:139, 1999. PUBMED Abstract
  66. Stanley RL, Fleck RA, Becker DL, et al: Gap junction protein expression and cellularity: comparison of immature and adult equine digital tendon, J Anat 211:325, 2007. PUBMED Abstract
  67. Parkin TD, Clegg PD, French NP, et al: Risk factors for fatal lateral condylar fracture of the third metacarpus/metatarsus in UK racing, Equine Vet J 37:192, 2005. PUBMED Abstract
  68. Raleigh SM, van der Merwe L, Ribbans WJ, et al: Variants within the MMP3 gene are associated with Achilles tendinopathy: possible interaction with the COL5A1 gene, Br J Sports Med 43:514, 2009. PUBMED Abstract
  69. Mokone GG, Schwellnus MP, Noakes TD, et al: The COL5A1 gene and Achilles tendon pathology, Scand J Med Sci Sports 16:19, 2006. PUBMED Abstract
  70. Mokone GG, Gajjar M, September AV, et al: The guanine-thymine dinucleotide repeat polymorphism within the tenascin-C gene is associated with Achilles tendon injuries, Am J Sports Med 33:1016, 2005. PUBMED Abstract
  71. Oki H, Miyake T, Kasashima Y, et al: Estimation of heritability for superficial digital flexor tendon injury by Gibbs sampling in the Thoroughbred racehorse, J Anim Breed Genet 125:413, 2008. PUBMED Abstract
  72. Weller R, Pfau T, Verheyen K, et al: The effect of conformation on orthopaedic health and performance in a cohort of National Hunt racehorses: preliminary results, Equine Vet J 38:622, 2006. PUBMED Abstract
  73. Birch HL, Wilson AM, Goodship AE: The effect of exercise-induced localised hyperthemia on tendon cell survival, J Exp Biol 200:1703, 1997. PUBMED Abstract
  74. Burrows S: Personal communication, 2008.
  75. Birch HL, Rutter GA, Goodship AE: Oxidative energy metabolism in equine tendon cells, Res Vet Sci 62:93, 1997. PUBMED Abstract
  76. Anstrom M, Westlin N: Blood flow in chronic Achilles tendinopathy, Clin Orthop 308:166, 1994. PUBMED Abstract
  77. Józsa L, Bálint BJ, Réffy A, et al: Hypoxic alterations of tenocytes in degenerative tendinopathy, Arch Orthop Trauma Surg 99:243, 1982. PUBMED Abstract
  78. Dalton S, Cawston TE, Riley GP: Human shoulder tendon biopsy samples in organ culture produce procollagenase and tissue inhibitor of metalloproteinases, Ann Rheum Dis 54:571, 1995. PUBMED Abstract
  79. Rees SG, Flannery CR, Little CB, et al: Catabolism of aggrecan, decorin and biglycan in tendon, Biochem J 350:181, 2000. PUBMED Abstract
  80. Dudhia J, Scott CM, Draper ER, et al: Aging enhances a mechanically-induced reduction in tendon strength by an active process involving matrix metalloproteinase activity, Aging Cell 6:547, 2007. PUBMED Abstract
  81. Platt DP, Wilson AM, Timbs A, et al: An investigation of the biomechanics of equine flexor tendon using an implantable microforce leaf, J Biomech 24:449, 1991.
  82. Meershoek L: Calculation of forelimb tendon forces in horses, PhD thesis, Utrecht, 2001, University of Utrecht.
  83. Anderson TM, McIlwraith CW, Douay P: The role of conformation in musculoskeletal problems in the racing Thoroughbred, Equine Vet J 36:571, 2004. PUBMED Abstract
  84. Denoix J-M: Functional anatomy of tendons and ligaments in the distal limbs (manus and pes), Vet Clin North Am Equine Pract 10:273, 1994. PUBMED Abstract
  85. Riemersma DJ, van den Bogert AJ: Influence of shoeing on ground reaction forces and tendon strains in the forelimbs of ponies, Equine Vet J 28:126, 1996. PUBMED Abstract
  86. Kasashima Y, Takahashi T, Birch HL, et al: Can exercise modulate the maturation of functionally different immature tendons in the horse? J Appl Physiol 104:416, 2008. PUBMED Abstract
  87. Smith RKW, Goodship AE: The effect of early training and the adaptation and conditioning of skeletal tissues, Vet Clin North Am Equine Pract 2008. PUBMED Abstract
  88. Kasashima Y, Smith RK, Birch HL, et al: Exercise-induced tendon hypertrophy: cross-sectional area changes during growth are influenced by exercise, Equine Vet J Suppl 34:264, 2002. PUBMED Abstract
  89. Williams RB, Harkins LS, Hammond CJ, et al: Racehorse injuries, clinical problems and fatalities recorded on British racecourses from flat racing and National Hunt racing during 1996, 1997 and 1998, Equine Vet J 33:478, 2001. PUBMED Abstract
  90. Hill AE, Stover SM, Gardner IA, et al: Risk factors for and outcomes of noncatastrophic suspensory apparatus injury in Thoroughbred racehorse, J Am Vet Med Assoc 218:1136, 2001. PUBMED Abstract
  91. Ely ER, Verheyen KL, Wood JL: Fractures and tendon injuries in National Hunt horses in training in the UK: a pilot study, Equine Vet J 36:365, 2004. PUBMED Abstract
  92. Smith RK, Heinegård D: Cartilage oligomeric matrix protein (COMP) levels in digital sheath synovial fluid and serum with tendon injury, Equine Vet J 32:52, 2000. PUBMED Abstract
  93. Fackelmann GE: The nature of tendon damage and its repair, Equine Vet J 5:141, 1973.
  94. Dahlgren LA, Mohammed HO, Nixon AJ: Temporal expression of growth factors and matrix molecules in healing tendon lesions, J Orthop Res 23:84, 2005. PUBMED Abstract
  95. Kajikawa Y, Morihara T, Sakamoto H, et al: GFP chimeric models exhibited a biphasic pattern of mesenchymal cell invasion in tendon healing, J Cell Physiol 210:684, 2007. PUBMED Abstract
  96. Williams IF, McCullagh KG, Silver IA: The distribution of types I and III collagen and fibronectin in the healing equine tendon, Connect Tissue Res 12:211, 1984. PUBMED Abstract
  97. Dahlgren LA, Brower-Toland BD, Nixon AJ: Cloning and expression of type III collagen in normal and injured tendons of horses, Am J Vet Res 66:266, 2005. PUBMED Abstract
  98. Watkins JP, Auer JA, Morgan SJ, et al: Healing of surgically created defects in the equine superficial digital flexor tendon: collagen-type transformation and tissue morphologic reorganization, Am J Vet Res 46:2091, 1985. PUBMED Abstract
  99. Crevier-Denoix N, Collobert C, Pourcelot P, et al: Mechanical properties of pathological equine superficial digital flexor tendons, Equine Vet J 23:23, 1997. PUBMED Abstract
  100. Birch HL: Personal communication, 2001.